Irf4 binding motif

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WebApr 24, 2024 · The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to … WebMUM1 / IRF4 is a nuclear marker that is normally expressed in activated B and T cells, plasma cells and melanocytes. Involved in the differentiation of B cells and T cells. Marker …

DNA sequences flanking identical AICE motifs regulate BATF-IRF4 …

WebDec 10, 2024 · IRF4 acts at the two key stages of pre-B cells, negatively regulating pre-B cell expansion and promoting L chain rearrangement and transcription, directly binding to Ig kappa (k) and lambda enhancer. IRF4 was originally discovered as the partner of the Ets transcription factor PU.1 in the immunoglobulin k light chain enhancer [ 5 ]. WebOct 10, 2024 · To investigate whether PDGF D has any biological functions independent of its ability to activate β-PDGFR possibly via the CUB domain, three arginine residues in the R 340 R 341 GR 343 motif within the GFD, known to be critical for its binding to β-PDGFR, were mutated to alanines (TM). 26 To purify recombinant GFD-D proteins, the CUB domain ... birds for sale vancouver island

The role of IRF-4 in transcriptional regulation - PubMed

WebSep 2, 2024 · IRF4 and DNA-Binding Motifs IRF4 belongs to the IRF gene family, which encodes basic leucine zipper (bZIP)-type transcription factor proteins. bZIP proteins possess three modular functional regions: dimerization, DNA binding, and transcriptional regulation regions. WebMar 14, 2024 · The IRF4 protein acts like a switch that turns on and off some genes involved in the body’s response to infection. In patients with this mutation, the IRF4 protein does not work as it should. Guérin et al. suggest that Whipple’s disease may be caused by specific genetic mutations affecting the immune system in subjects infected by T. whipplei. WebDec 17, 2024 · BATF and IRF4 bind to AP-1-IRF-composite element (AICE) motifs 37, 38, 39, 40, but how BATF and other AP-1 transcription factors regulate IRF4 activity in the eTreg transcriptional program is... dana snyder scratch

Specificity through cooperation: BATF–IRF interactions ... - Nature

The dynamic functions of IRF4 in B cell malignancies

WebAug 25, 2024 · IRF4 is critical to full T cell activation, metabolic upregulation, and function but binds DNA weakly on its own and depends on interactions with other transcription … WebSep 1, 2006 · The mammalian IRF family comprises nine members: IRF1, IRF2, IRF3, IRF4 (also known as LSIRF, PIP or ICSAT), IRF5, IRF6, IRF7, IRF8 (also known as ICSBP) and IRF9 (also known as ISGF3γ) 4, 5.... dana speer century 21WebAug 1, 2024 · PU.1 bound to the CNS3 probe even when the IRF4 binding motif was mutated , probably because the remaining Ets motif in the mutated probe can be bound with monomeric PU.1. To clarify whether PU.1 binds to CNS3 by itself in living cells, we evaluated the effect of IRF4 knockdown on the binding degree of PU.1 to the EICE in CNS3 by a ChIP … birds for sale townsville area

"WebIRF4 IRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. From: The Immune Response, 2006 Related terms: CD4 IRF8 T Cells Plasma Cell Lymphoma Germinal Center Cellular Differentiation Phenotype B Cell Proteome " - Irf4 binding motif

Irf4 binding motif

The role of IRF-4 in transcriptional regulation - PubMed

WebMar 1, 2015 · Motif analysis of the chicken ovalbumin upstream promoter-transcription factor II DNA-binding intervals revealed an enrichment in FOXO1 motifs . The role of IRF4 in the modulation of inflammation and immune response in differentiating HESCs remains to … WebTo optimize motif analysis to distinguish sequence requirements of high-affinity versus a low-affinity AICEs, we needed to identify which motif(s) within a peak were functional for BATF/IRF4...

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WebIRF-4 was initially characterized in lymphocytes and was shown to function as both a transcriptional repressor and activator. More recently, IRF-4 expression and function have … WebFeb 26, 2024 · Interferon regulatory factor 4 (IRF4) is a key transcription factor (TF) in the regulation of immune cells, including B and T cells. It acts by binding DNA as both a homodimer and, in conjunction with other TFs, as a heterodimer. The choice of homo and heterodimeric/ DNA interactions is a critical a …

WebApr 4, 2024 · IRF4 protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter. We propose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentration-dependent activity of Irf4 "writes" T helper fate choice. WebJan 20, 2024 · Abstract. Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) and key regulator of immune cell development and function. We report a recurrent …

WebNational Center for Biotechnology Information WebJul 17, 2015 · The AICE motif directs assembly of IRF4 or IRF8 (601565) with BATF heterodimers and is also used in TH2, B, and dendritic cells. ... (164720) or Ap1 (165160) binding sites with Pu.1 (SPI1; 165170) or Batf (612476). At higher concentrations, Irf4 binding shifted to interferon sequence response elements, and these enriched for genes …

WebIRF4, a member of the interferon regulatory factor (IRF) family, was previously shown to be restricted in the immune system and involved in the differentiation of immune cells. …

WebIRF4 binds to the canonical IFN-stimulated response elements (ISREs) as a homodimer, and it engages erythroblast transformation-specific IRF composite elements (EICEs) and activating protein 1... dan a speakman constructionWebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell … dana southernWebDec 18, 2009 · Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo and furthermore revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. birds for sale victoriaWebMay 23, 2013 · At higher concentrations, IRF4 binding shifted to interferon sequence response motifs; these enriched for genes involved in plasma cell differentiation. Our results support a model of “kinetic control” in which signaling-induced dynamics of IRF4 in activated B cells control their cell-fate outcomes. Graphical Abstract dana spicer 30/44 wheel hub assembly jkWebIRF4 is expressed at a lower level than IRF8 in these progenitor cells; however, IRF4 expression appears to be particularly important for the development of M2 macrophages. … dana spicer axle shaftWebMar 19, 2024 · In addition, we analyzed the distribution of DNA binding motifs within ±3 kilobase pairs (kb) from the sites bound by both IRF4 and NF-κB (Figure 2F; supplemental Table 4). As expected, both IRF and NF-κB binding motifs were enriched at the center of transcription factor binding sites. birds for sale perthWebFeb 4, 2024 · IRF4 plays important roles in controlling the stimulatory properties of DCs but the mechanisms and contexts by which these are deployed to regulate Th responses are less well understood ( Bajaña et al., 2012; Vander Lugt et al., 2014 ). dana space city alchemy