WebIn addition, BPTES nanoparticles had no effect on the plasma levels of liver enzymes in contrast to CB-839, a glutaminase inhibitor that is currently in clinical trials. In a mouse model using orthotopic transplantation of … WebAug 24, 2016 · Clinical trials are needed to determine whether combination therapy, with drugs that effectively block the metabolism of glutamine and glucose, improves the survival of patients with pancreatic ...
Drug-induced amino acid deprivation as strategy for cancer therapy
WebDec 3, 2024 · BPTES was discovered via screening of compounds that inhibit glutaminase and showed in vivo activity in a MYC ... IM156 has been studied in a phase I clinical trial for solid tumours and lymphoma ... WebJul 27, 2024 · Currently, glutaminase inhibitor is under clinical trial for testing anti-cancer efficacy. Clinical data suggests that asparagine depletion is effective in treating hematologic malignancies even as a single agent. ... BPTES and CB-839, in which the anti-cancer activity have been studied in vitro or in vivo [40, 41, 53,54,55,56,57,58,59]. jeff brusa lodi ca
Combination therapy with BPTES nanoparticles and metformin …
WebExplore 448,116 research studies in all 50 states and in 221 countries. See listed clinical studies related to the coronavirus disease (COVID-19) ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine. IMPORTANT: Listing a study does not mean it has been evaluated by the U.S. Federal Government. WebJul 27, 2024 · Currently, glutaminase inhibitor is under clinical trial for testing anti-cancer efficacy. Clinical data suggests that asparagine depletion is effective in treating … WebSep 3, 2013 · Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) also potently inhibits GLS isoforms encoded by GLS . BPTES impairs ATP levels and growth … jeff brohm bio